Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin

Background: The displacement of l-thyroxine (T(4)) from binding sites on transthyretin (TTR) is considered a significant contributing mechanism in polychlorinated biphenyl (PCB)-induced thyroid disruption. Previous research has discovered hydroxylated PCB metabolites (OH-PCBs) as high-affinity ligan...

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Hauptverfasser: Grimm, Fabian A., Lehmler, Hans-Joachim, He, Xianran, Robertson, Larry W., Duffel, Michael W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Institute of Environmental Health Sciences 2013
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672920/
https://ncbi.nlm.nih.gov/pubmed/23584369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1206198
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