Enzymes as reagents in peptide synthesis: enzymatic removal of amine protecting groups.
A model system is described for the enzymatic deprotection of suitably masked amino groups during stepwise peptide synthesis. Nitrophenyl esters of amino acids, N-protected with trypsin-labile benzyloxycarbonylarginyl groups, were prepared as crystalline, analytically pure picrate salts in a standar...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1975
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1056024/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.6.2193 |
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