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Enzymes as reagents in peptide synthesis: enzymatic removal of amine protecting groups.

A model system is described for the enzymatic deprotection of suitably masked amino groups during stepwise peptide synthesis. Nitrophenyl esters of amino acids, N-protected with trypsin-labile benzyloxycarbonylarginyl groups, were prepared as crystalline, analytically pure picrate salts in a standar...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Meyers, C, Glass, J D
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1975
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1056024/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.6.2193
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