In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice

In mtDNA mutator mice, mtDNA mutations accumulate leading to a rapidly aging phenotype. However, there is little evidence of oxidative damage to tissues, and when analyzed ex vivo, no change in production of the reactive oxygen species (ROS) superoxide and hydrogen peroxide by mitochondria has been...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Logan, Angela, Shabalina, Irina G, Prime, Tracy A, Rogatti, Sebastian, Kalinovich, Anastasia V, Hartley, Richard C, Budd, Ralph C, Cannon, Barbara, Murphy, Michael P
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Short Takes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326952/
https://ncbi.nlm.nih.gov/pubmed/24621297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12212
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