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Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis
Senescent cells secrete a plethora of factors with potent paracrine signaling capacity. Strikingly, senescence, which acts as defense against cell transformation, exerts pro-tumorigenic activities through its secretome by promoting tumor-specific features, such as cellular proliferation, epithelial-...
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| Udgivet i: | Aging Cell |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BlackWell Publishing Ltd
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4326894/ https://ncbi.nlm.nih.gov/pubmed/24589226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12197 |
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