Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

Endothelial dysfunction is a major contributor to cardiovascular disease (CVD), particularly in elderly people. Studies have demonstrated the role of glycation in endothelial dysfunction in nonphysiological models, but the physiological role of glycation in age-related endothelial dysfunction has be...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Jo-Watanabe, Airi, Ohse, Takamoto, Nishimatsu, Hiroaki, Takahashi, Masao, Ikeda, Yoichiro, Wada, Takehiko, Shirakawa, Jun-ichi, Nagai, Ryoji, Miyata, Toshio, Nagano, Tetsuo, Hirata, Yasunobu, Inagi, Reiko, Nangaku, Masaomi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326886/
https://ncbi.nlm.nih.gov/pubmed/24612481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12204
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