Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes

Recent studies have highlighted the renoprotective effect of sirtuin1 (SIRT1), a deacetylase that contributes to cellular regulation. However, the pathophysiologic role of SIRT1 in podocytes remains unclear. Here, we investigated the function of SIRT1 in podocytes. We first established podocyte-spec...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Motonishi, Shuta, Nangaku, Masaomi, Wada, Takehiko, Ishimoto, Yu, Ohse, Takamoto, Matsusaka, Taiji, Kubota, Naoto, Shimizu, Akira, Kadowaki, Takashi, Tobe, Kazuyuki, Inagi, Reiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520160/
https://ncbi.nlm.nih.gov/pubmed/25424328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014030289
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