Low Intracellular Iron Increases the Stability of Matriptase-2

Matriptase-2 (MT2) is a type II transmembrane serine protease that is predominantly expressed in hepatocytes. It suppresses the expression of hepatic hepcidin, an iron regulatory hormone, by cleaving membrane hemojuvelin into an inactive form. Hemojuvelin is a bone morphogenetic protein (BMP) co-rec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhao, Ningning, Nizzi, Christopher P., Anderson, Sheila A., Wang, Jiaohong, Ueno, Akiko, Tsukamoto, Hidekazu, Eisenstein, Richard S., Enns, Caroline A., Zhang, An-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326848/
https://ncbi.nlm.nih.gov/pubmed/25550162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611913
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