Tau Monoclonal Antibody Generation Based on Humanized Yeast Models: IMPACT ON TAU OLIGOMERIZATION AND DIAGNOSTICS

A link between Tau phosphorylation and aggregation has been shown in different models for Alzheimer disease, including yeast. We used human Tau purified from yeast models to generate new monoclonal antibodies, of which three were further characterized. The first antibody, ADx201, binds the Tau proli...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Rosseels, Joëlle, Van den Brande, Jeff, Violet, Marie, Jacobs, Dirk, Grognet, Pierre, Lopez, Juan, Huvent, Isabelle, Caldara, Marina, Swinnen, Erwin, Papegaey, Anthony, Caillierez, Raphaëlle, Buée-Scherrer, Valerie, Engelborghs, Sebastiaan, Lippens, Guy, Colin, Morvane, Buée, Luc, Galas, Marie-Christine, Vanmechelen, Eugeen, Winderickx, Joris
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326816/
https://ncbi.nlm.nih.gov/pubmed/25540200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627919
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