Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells

AIM: The pentose phosphate pathway (PPP) is involved in the activity of glucose-6-phosphate dehydrogenase (G6PD) and generation of NADPH, which plays a key role in drug metabolism. The aim of this study was to investigate the effects of modulation of the PPP on drug metabolism capacity in vitro. MET...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Xiao, Wen-jing, Ma, Ting, Ge, Chun, Xia, Wen-juan, Mao, Yong, Sun, Run-bin, Yu, Xiao-yi, Aa, Ji-ye, Wang, Guang-ji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326794/
https://ncbi.nlm.nih.gov/pubmed/25619394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.137
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