Bisindolylmaleimide alkaloid BMA-155Cl induces autophagy and apoptosis in human hepatocarcinoma HepG-2 cells through the NF-κB p65 pathway

Bisindolylmaleimides, a series of derivatives of a PKC inhibitor staurosporine, exhibit potential as anti-cancer drugs and have received considerable attention in clinical trials. This study aims to investigate the effects of a bisindolylmaleimide alkaloid 155Cl (BMA-155Cl) with a novel structure on...

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Publicat a:Acta Pharmacol Sin
Autors principals: Sun, Xiao, Li, Lin, Ma, Hong-guang, Sun, Pu, Wang, Qi-lin, Zhang, Ting-ting, Shen, Yue-mao, Zhu, Wei-ming, Li, Xia
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386318/
https://ncbi.nlm.nih.gov/pubmed/28260799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.171
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