Tumor suppressor role of Notch3 in Medullary Thyroid Carcinoma revealed by genetic and pharmacological induction

Notch1-3 are transmembrane receptors that appear to be absent in Medullary Thyroid Cancer (MTC). Previous research has shown that induction of Notch1 has a tumor suppressor effect in MTC cell lines, but little is known about the biological consequences of Notch3 activation for the progression of the...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Jaskula-Sztul, Renata, Eide, Jacob, Tesfazghi, Sara, Dammalapati, Ajitha, Harrison, April D., Yu, Xiao-Min, Scheinebeck, Casi, Winston-McPherson, Gabrielle, Kupcho, Kevin R., Robers, Matthew B., Hundal, Amrit K., Tang, Weiping, Chen, Herbert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326595/
https://ncbi.nlm.nih.gov/pubmed/25512616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0073
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