Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis

Macroautophagy selectively degrades dysfunctional mitochondria by a process known as mitophagy. Here we demonstrate the involvement of transglutaminase 2 (TG2) in the turnover and degradation of damaged mitochondria. In TG2-ablated cells we observed the presence of a large number of fragmented mitoc...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Rossin, F, D'Eletto, M, Falasca, L, Sepe, S, Cocco, S, Fimia, G M, Campanella, M, Mastroberardino, P G, Farrace, M G, Piacentini, M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326569/
https://ncbi.nlm.nih.gov/pubmed/25060553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.106
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires