Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis

Macroautophagy selectively degrades dysfunctional mitochondria by a process known as mitophagy. Here we demonstrate the involvement of transglutaminase 2 (TG2) in the turnover and degradation of damaged mitochondria. In TG2-ablated cells we observed the presence of a large number of fragmented mitoc...

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Опубликовано в: :Cell Death Differ
Главные авторы: Rossin, F, D'Eletto, M, Falasca, L, Sepe, S, Cocco, S, Fimia, G M, Campanella, M, Mastroberardino, P G, Farrace, M G, Piacentini, M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326569/
https://ncbi.nlm.nih.gov/pubmed/25060553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.106
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