The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

Breast cancer bone micrometastases can remain asymptomatic for years before progressing into overt lesions. The biology of this process, including the microenvironment niche and supporting pathways, is unclear. We find that bone micrometastases predominantly reside in a niche that exhibits features...

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Publicado en:Cancer Cell
Autores principales: Wang, Hai, Yu, Cuijuan, Gao, Xia, Welte, Thomas, Muscarella, Aaron M., Tian, Lin, Zhao, Hong, Zhao, Zhen, Du, Shiyu, Tao, Jianning, Lee, Brendan, Westbrook, Thomas F., Wong, Stephen T. C., Jin, Xin, Rosen, Jeffrey M., Osborne, C. Kent, Zhang, Xiang H.-F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326554/
https://ncbi.nlm.nih.gov/pubmed/25600338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.017
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