Intravenous Administration of Retroviral Replicating Vector, Toca 511, Demonstrates Therapeutic Efficacy in Orthotopic Immune-Competent Mouse Glioma Model

Toca 511 (vocimagene amiretrorepvec), a nonlytic, amphotropic retroviral replicating vector (RRV), encodes and delivers a functionally optimized yeast cytosine deaminase (CD) gene to tumors. In orthotopic glioma models treated with Toca 511 and 5-fluorocytosine (5-FC) the CD enzyme within infected c...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Huang, Tiffany T., Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M., Lopez Espinoza, Fernando, Martin, Bryan, Ibañez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Pertschuk, Daniel, Jolly, Douglas J., Robbins, Joan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326030/
https://ncbi.nlm.nih.gov/pubmed/25419577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2014.100
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