Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.
Cells of the MPC-11 mouse myeloma cell line, which produces an IgG2b immunoglobulin, were subjected to mutagenesis with Melphalan or with ICR-191, after which they were cloned in soft agar. Approximately 0.5 percent of the clones produced altered heavy chains that: (i) were the same size as or large...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1975
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432548/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/805428/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.4.1427 |
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