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Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

Cells of the MPC-11 mouse myeloma cell line, which produces an IgG2b immunoglobulin, were subjected to mutagenesis with Melphalan or with ICR-191, after which they were cloned in soft agar. Approximately 0.5 percent of the clones produced altered heavy chains that: (i) were the same size as or large...

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Autori principali: Preud'Homme, J L, Birshtein, B K, Scharff, M D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1975
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC432548/
https://ncbi.nlm.nih.gov/pubmed/805428
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