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Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

Cells of the MPC-11 mouse myeloma cell line, which produces an IgG2b immunoglobulin, were subjected to mutagenesis with Melphalan or with ICR-191, after which they were cloned in soft agar. Approximately 0.5 percent of the clones produced altered heavy chains that: (i) were the same size as or large...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Preud'Homme, J L, Birshtein, B K, Scharff, M D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1975
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432548/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/805428/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.4.1427
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