The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines

In epithelial cells, miRNA-199a-5p/-3p and Brm, a catalytic subunit of the SWI/SNF complex were previously shown to form a double-negative feedback loop through EGR1, by which human cancer cell lines tend to fall into either of the steady states, types 1 [miR-199a(−)/Brm(+)/EGR1(−)] and 2 [miR-199a(...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kobayashi, Kazuyoshi, Sakurai, Kouhei, Hiramatsu, Hiroaki, Inada, Ken-ichi, Shiogama, Kazuya, Nakamura, Shinya, Suemasa, Fumiko, Kobayashi, Kyosuke, Imoto, Seiya, Haraguchi, Takeshi, Ito, Hiroaki, Ishizaka, Aya, Tsutsumi, Yutaka, Iba, Hideo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325331/
https://ncbi.nlm.nih.gov/pubmed/25673149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08428
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