14-3-3ζ turns TGF-β’s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2

Transforming growth factor-β (TGF-β) functions as a tumor suppressor in pre-malignant cells but as a metastasis promoter in cancer cells. The dichotomous functions of TGF-β are proposed to be dictated by different partners of its downstream effectors Smads. However, the mechanism for the contextual...

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Udgivet i:Cancer Cell
Main Authors: Xu, Jia, Acharya, Sunil, Sahin, Ozgur, Zhang, Qingling, Saito, Yohei, Yao, Jun, Wang, Hai, Li, Ping, Zhang, Lin, Lowery, Frank J, Kuo, Wen-Ling, Xiao, Yi, Ensor, Joe, Sahin, Aysegul A, Zhang, Xiang H.-F., Hung, Mien-Chie, Zhang, Jitao David, Yu, Dihua
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325275/
https://ncbi.nlm.nih.gov/pubmed/25670079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.025
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