Nonirradiated NOD,B6.SCID Il2rγ(−/−)Kit(W41/W41) (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

In this study, we demonstrate a newly derived mouse model that supports engraftment of human hematopoietic stem cells (HSCs) in the absence of irradiation. We cross the NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ (NSG) strain with the C57BL/6J-Kit(W-41J)/J (C57BL/6.Kit(W41)) strain and engraft, without irra...

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Publicado en:Stem Cell Reports
Main Authors: McIntosh, Brian E., Brown, Matthew E., Duffin, Bret M., Maufort, John P., Vereide, David T., Slukvin, Igor I., Thomson, James A.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325197/
https://ncbi.nlm.nih.gov/pubmed/25601207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.12.005
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