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Engineering of Glarea lozoyensis for Exclusive Production of the Pneumocandin B(0) Precursor of the Antifungal Drug Caspofungin Acetate
Pneumocandins produced by the fungus Glarea lozoyensis are acylated cyclic hexapeptides of the echinocandin family. Pneumocandin B(0) is the starting molecule for the first semisynthetic echinocandin antifungal drug, caspofungin acetate. In the wild-type strain, pneumocandin B(0) is a minor fermenta...
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| Publicado no: | Appl Environ Microbiol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4325176/ https://ncbi.nlm.nih.gov/pubmed/25527531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03256-14 |
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