Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis

BACKGROUND: The antifungal therapy caspofungin is a semi-synthetic derivative of pneumocandin B(0), a lipohexapeptide produced by the fungus Glarea lozoyensis, and was the first member of the echinocandin class approved for human therapy. The nonribosomal peptide synthetase (NRPS)-polyketide synthas...

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Hlavní autoři: Chen, Li, Yue, Qun, Zhang, Xinyu, Xiang, Meichun, Wang, Chengshu, Li, Shaojie, Che, Yongsheng, Ortiz-López, Francisco Javier, Bills, Gerald F, Liu, Xingzhong, An, Zhiqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672099/
https://ncbi.nlm.nih.gov/pubmed/23688303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-339
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