Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells

Shikonin (SHK), a natural small agent (MW 288.3), reportedly induces cell death in various tumor cells. We have found that SHK also exerts potent cytocidal effects on human multiple myeloma (MM) cells, but its anticancer mechanism in MM cells remains to be elucidated. SHK at 2.5–5 μM induced apoptos...

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Vydáno v:Int J Oncol
Hlavní autoři: WADA, NAOKO, KAWANO, YAWARA, FUJIWARA, SHIHO, KIKUKAWA, YOSHITAKA, OKUNO, YUTAKA, TASAKI, MASAYOSHI, UEDA, MITSUHARU, ANDO, YUKIO, YOSHINAGA, KAZUYA, RI, MASAKI, IIDA, SHINSUKE, NAKASHIMA, TAKAYUKI, SHIOTSU, YUKIMASA, MITSUYA, HIROAKI, HATA, HIROYUKI
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2014
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324584/
https://ncbi.nlm.nih.gov/pubmed/25530098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2804
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