Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells

Shikonin (SHK), a natural small agent (MW 288.3), reportedly induces cell death in various tumor cells. We have found that SHK also exerts potent cytocidal effects on human multiple myeloma (MM) cells, but its anticancer mechanism in MM cells remains to be elucidated. SHK at 2.5–5 μM induced apoptos...

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Bibliographic Details
Published in:Int J Oncol
Main Authors: WADA, NAOKO, KAWANO, YAWARA, FUJIWARA, SHIHO, KIKUKAWA, YOSHITAKA, OKUNO, YUTAKA, TASAKI, MASAYOSHI, UEDA, MITSUHARU, ANDO, YUKIO, YOSHINAGA, KAZUYA, RI, MASAKI, IIDA, SHINSUKE, NAKASHIMA, TAKAYUKI, SHIOTSU, YUKIMASA, MITSUYA, HIROAKI, HATA, HIROYUKI
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324584/
https://ncbi.nlm.nih.gov/pubmed/25530098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2804
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