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Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells
Shikonin (SHK), a natural small agent (MW 288.3), reportedly induces cell death in various tumor cells. We have found that SHK also exerts potent cytocidal effects on human multiple myeloma (MM) cells, but its anticancer mechanism in MM cells remains to be elucidated. SHK at 2.5–5 μM induced apoptos...
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| Published in: | Int J Oncol |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
D.A. Spandidos
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324584/ https://ncbi.nlm.nih.gov/pubmed/25530098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2804 |
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