Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells

Shikonin (SHK), a natural small agent (MW 288.3), reportedly induces cell death in various tumor cells. We have found that SHK also exerts potent cytocidal effects on human multiple myeloma (MM) cells, but its anticancer mechanism in MM cells remains to be elucidated. SHK at 2.5–5 μM induced apoptos...

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Publicado en:Int J Oncol
Autores principales: WADA, NAOKO, KAWANO, YAWARA, FUJIWARA, SHIHO, KIKUKAWA, YOSHITAKA, OKUNO, YUTAKA, TASAKI, MASAYOSHI, UEDA, MITSUHARU, ANDO, YUKIO, YOSHINAGA, KAZUYA, RI, MASAKI, IIDA, SHINSUKE, NAKASHIMA, TAKAYUKI, SHIOTSU, YUKIMASA, MITSUYA, HIROAKI, HATA, HIROYUKI
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324584/
https://ncbi.nlm.nih.gov/pubmed/25530098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2804
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