Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells

Shikonin (SHK), a natural small agent (MW 288.3), reportedly induces cell death in various tumor cells. We have found that SHK also exerts potent cytocidal effects on human multiple myeloma (MM) cells, but its anticancer mechanism in MM cells remains to be elucidated. SHK at 2.5–5 μM induced apoptos...

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Detaylı Bibliyografya
Yayımlandı:Int J Oncol
Asıl Yazarlar: WADA, NAOKO, KAWANO, YAWARA, FUJIWARA, SHIHO, KIKUKAWA, YOSHITAKA, OKUNO, YUTAKA, TASAKI, MASAYOSHI, UEDA, MITSUHARU, ANDO, YUKIO, YOSHINAGA, KAZUYA, RI, MASAKI, IIDA, SHINSUKE, NAKASHIMA, TAKAYUKI, SHIOTSU, YUKIMASA, MITSUYA, HIROAKI, HATA, HIROYUKI
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: D.A. Spandidos 2014
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324584/
https://ncbi.nlm.nih.gov/pubmed/25530098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2804
Etiketler: Etiketle
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