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De Novo Design of Self-Assembling Foldamers That Inhibit Heparin–Protein Interactions

[Image: see text] A series of self-associating foldamers have been designed as heparin reversal agents, as antidotes to prevent bleeding due to this potent antithrombotic agent. The foldamers have a repeating sequence of Lys-Sal, in which Sal is 5-amino-2-methoxy-benzoic acid. These foldamers are de...

詳細記述

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書誌詳細
出版年:ACS Chem Biol
主要な著者: Montalvo, Geronda L., Zhang, Yao, Young, Trevor M., Costanzo, Michael J., Freeman, Katie B., Wang, Jun, Clements, Dylan J., Magavern, Emma, Kavash, Robert W., Scott, Richard W., Liu, Dahui, DeGrado, William F.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324449/
https://ncbi.nlm.nih.gov/pubmed/24491145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500026x
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