De Novo Design of Self-Assembling Foldamers That Inhibit Heparin–Protein Interactions

[Image: see text] A series of self-associating foldamers have been designed as heparin reversal agents, as antidotes to prevent bleeding due to this potent antithrombotic agent. The foldamers have a repeating sequence of Lys-Sal, in which Sal is 5-amino-2-methoxy-benzoic acid. These foldamers are de...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Montalvo, Geronda L., Zhang, Yao, Young, Trevor M., Costanzo, Michael J., Freeman, Katie B., Wang, Jun, Clements, Dylan J., Magavern, Emma, Kavash, Robert W., Scott, Richard W., Liu, Dahui, DeGrado, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324449/
https://ncbi.nlm.nih.gov/pubmed/24491145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500026x
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