Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly

Amyloid fibrils are self-propagating entities that spread pathology in several devastating disorders including Alzheimer's disease (AD). In AD, amyloid-β (Aβ) peptides form extracellular plaques that contribute to cognitive decline. One potential therapeutic strategy is to develop inhibitors th...

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Detalhes bibliográficos
Main Authors: Seither, Katelyn M., McMahon, Heather A., Singh, Nikita, Wang, Hejia, Cushman-Nick, Mimi, Montalvo, Geronda L., DeGrado, William F., Shorter, James
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209162/
https://ncbi.nlm.nih.gov/pubmed/25142005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131609
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