IL-27 and Type-2 immunity in asthma: Association with severity, CXCL9 and STAT signaling

BACKGROUND: Severe asthma may involve both innate and Type-2 cytokine associated adaptive immunity. While IL-27 has been reported to potentiate Th1 responses (including the chemokine CXCL9) and suppress Th2 responses, its function in asthma is unknown. OBJECTIVE: Evaluate IL-27 expression in human a...

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Bibliografiske detaljer
Udgivet i:J Allergy Clin Immunol
Main Authors: Xie, Min, Mustovich, Anthony T., Jiang, Yi, Trudeau, John B., Ray, Anuradha, Ray, Prabir, Hu, Haizhen, Holguin, Fernando, Freeman, Bruce, Wenzel, Sally E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324337/
https://ncbi.nlm.nih.gov/pubmed/25312760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.08.023
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