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Deficiency of antigen-specific B cells results in decreased Trypanosoma cruzi systemic but not mucosal immunity due to CD8 T cell exhaustion

Vaccines against mucosally invasive, intracellular pathogens must induce a myriad of immune responses in order to provide optimal mucosal and systemic protection, including CD4(+) T cells, CD8(+) T cells and antibody-producing B cells. In general, CD4(+) T cells are known to provide important helper...

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Bibliographic Details
Published in:J Immunol
Main Authors: Sullivan, Nicole L., Eickhoff, Christopher S., Sagartz, John, Hoft, Daniel F.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324165/
https://ncbi.nlm.nih.gov/pubmed/25595788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303163
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