The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene

Systemic sclerosis (SSc) is a polygenic, autoimmune disorder of unknown etiology, characterized by the excessive accumulation of extracellular matrix (ECM) proteins, vascular alterations, and autoantibodies. The tight skin (Tsk)2/+ mouse model of SSc demonstrates signs similar to SSc including tight...

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Publicado en:J Invest Dermatol
Main Authors: Long, Kristen B., Li, Zhenghui, Burgwin, Chelsea M., Choe, Susanna G., Martyanov, Viktor, Sassi-Gaha, Sihem, Earl, Josh, Eutsey, Rory, Ahmed, Azad, Ehrlich, Garth D., Artlett, Carol M., Whitfield, Michael L., Blankenhorn, Elizabeth P.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324084/
https://ncbi.nlm.nih.gov/pubmed/25330296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.455
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