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Understanding the Molecular Manipulation of DCAF1 by the Lentiviral Accessory Proteins Vpr and Vpx

Vpr and Vpx are primate lentivirus proteins that manipulate the cellular CRL4 ubiquitin ligase complex. While Vpr is common to all primate lentiviruses, Vpx is only encoded by HIV-2 and a limited range of SIVs. Although Vpr and Vpx share a high degree of homology they are known to induce markedly di...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Cassiday, Patrick A., DePaula-Silva, Ana Beatriz, Chumley, Jeffrey, Ward, Jeffrey, Barker, Edward, Planelles, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323848/
https://ncbi.nlm.nih.gov/pubmed/25499532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.11.024
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