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Assessing Recovery from Neurodegeneration in Spinocerebellar Ataxia 1: Comparison of in vivo Magnetic Resonance Spectroscopy with Motor Testing, Gene Expression and Histology

Suppression of transgene expression in a conditional transgenic mouse model of spinocerebellar ataxia 1 (SCA1) reverses the Purkinje cell pathology and motor dysfunction that are hallmarks of SCA1. We previously showed that cerebellar neurochemical levels measured by magnetic resonance spectroscopy...

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Publicado en:Neurobiol Dis
Autores principales: Öz, Gülin, Colonna, Emily, Demirgöz, Döne, Rainwater, Orion, Eberly, Lynn E., Orr, Harry T., Clark, H. Brent
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323665/
https://ncbi.nlm.nih.gov/pubmed/25446943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.11.011
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