Fitness Profiling Links Topoisomerase II Regulation of Centromeric Integrity to Doxorubicin Resistance in Fission Yeast

Doxorubicin, a chemotherapeutic agent, inhibits the religation step of topoisomerase II (Top2). However, the downstream ramifications of this action are unknown. Here we performed epistasis analyses of top2 with 63 genes representing doxorubicin resistance (DXR) genes in fission yeast and revealed a...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Nguyen, Thi Thuy Trang, Lim, Julia Sze Lynn, Tang, Richard Ming Yi, Zhang, Louxin, Chen, Ee Sin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323662/
https://ncbi.nlm.nih.gov/pubmed/25669599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08400
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