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An Arf-Egr-C/EBPβ Pathway Linked to Ras-Induced Senescence and Cancer
Oncogene-induced senescence (OIS) protects normal cells from transformation by Ras, whereas cells lacking p14/p19(Arf) or other tumor suppressors can be transformed. The transcription factor C/EBPβ is required for OIS in primary fibroblasts but is downregulated by H-Ras(V12) in immortalized NIH 3T3...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4323493/ https://ncbi.nlm.nih.gov/pubmed/25535333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01489-14 |
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