A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing

The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within genomic CpG islands. Somatic loss-of-function mutations of TET2 are frequent...

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Pubblicato in:Mol Cell Biol
Autori principali: Gjini, Evisa, Mansour, Marc R., Sander, Jeffry D., Moritz, Nadine, Nguyen, Ashley T., Kesarsing, Michiel, Gans, Emma, He, Shuning, Chen, Si, Ko, Myunggon, Kuang, You-Yi, Yang, Song, Zhou, Yi, Rodig, Scott, Zon, Leonard I., Joung, J. Keith, Rao, Anjana, Look, A. Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323485/
https://ncbi.nlm.nih.gov/pubmed/25512612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00971-14
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