Cerebral 5-HT(2A) receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice

Transgenic mice with knock-in (KI) of a tryptophan hydroxylase 2 (Tph2) R439H mutation, analogous to the Tph2 R441H single-nucleotide polymorphism originally identified in a late life depression cohort, have markedly reduced levels of 5-hydroxytryptamine (5-HT). These Tph2KI mice are therefore inter...

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Published in:Neurosci Lett
Main Authors: Jørgensen, Christinna V, Jacobsen, Jacob P, Caron, Marc G, Klein, Anders Bue, Knudsen, Gitte M, Mikkelsen, Jens D
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323164/
https://ncbi.nlm.nih.gov/pubmed/24055299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.08.073
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