Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

Homozygous knockout of p53 in mice leads to early mortality from lymphoma, with almost complete penetrance, thus hampering studies of other tumor histotypes related to p53 alterations. To avoid lymphoma development, we crossed p53 knockout mice (BALB-p53 mice) with alymphocytic BALB/c Rag2(−/−);Il2r...

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Vydáno v:Oncotarget
Hlavní autoři: Landuzzi, Lorena, Ianzano, Marianna L., Nicoletti, Giordano, Palladini, Arianna, Grosso, Valentina, Ranieri, Dario, Dall'Ora, Massimiliano, Raschi, Elena, Laranga, Roberta, Gambarotti, Marco, Picci, Piero, De Giovanni, Carla, Nanni, Patrizia, Lollini, Pier-Luigi
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322986/
https://ncbi.nlm.nih.gov/pubmed/25426555
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