Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor-α/PGC-1α Gene Regulatory Pathway

BACKGROUND: Obesity and diabetes mellitus are complex metabolic problems of pandemic proportion, contributing to significant cardiovascular mortality. Recent studies have shown altered mitochondrial function in the hearts of diabetic animals. We hypothesized that regulatory events involved in the co...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Duncan, Jennifer G., Fong, Juliet L., Medeiros, Denis M., Finck, Brian N., Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322937/
https://ncbi.nlm.nih.gov/pubmed/17261654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.106.662296
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