The Transcriptional Coactivators, PGC-1α and β, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

We previously demonstrated a cardiac mitochondrial biogenic response in insulin resistant mice that requires the nuclear receptor transcription factor PPARα. We hypothesized that the PPARα coactivator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) is necessary for mito...

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Autores principales: Mitra, Riddhi, Nogee, Daniel P., Zechner, Juliet F., Yea, Kyungmoo, Gierasch, Carrie M., Kovacs, Attila, Medeiros, Denis M., Kelly, Daniel P., Duncan, Jennifer G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294189/
https://ncbi.nlm.nih.gov/pubmed/22080103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.10.010
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