Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart

Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARγ coactivator-1 (PGC-1) α and β have been implicated in the transcriptional control of cellular energy metabolism. Mice with combined deficiency of PGC-1α and PGC-1β...

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Detalhes bibliográficos
Main Authors: Lai, Ling, Leone, Teresa C., Zechner, Christoph, Schaeffer, Paul J., Kelly, Sean M., Flanagan, Daniel P., Medeiros, Denis M., Kovacs, Attila, Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492740/
https://ncbi.nlm.nih.gov/pubmed/18628400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1661708
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