β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

BACKGROUND: The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecular subtypes of medulloblastoma (MB). In sonic hedgehog (Shh)-driven MB, activati...

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Publicat a:Mol Cancer
Autors principals: Zinke, Jenny, Schneider, Fabian T, Harter, Patrick N, Thom, Sonja, Ziegler, Nicole, Toftgård, Rune, Plate, Karl H, Liebner, Stefan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
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Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320815/
https://ncbi.nlm.nih.gov/pubmed/25645196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0294-4
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