Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity as judged by gel electrophoresis, using an in vitro complementation assay. It is a dimer of identical 110,000-dalton subunits. A polypeptide of this molecular weight is un...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Sugino, Akio, Peebles, Craig L., Kreuzer, Kenneth N., Cozzarelli, Nicholas R.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1977
Assuntos:	Biological Sciences: Biochemistry
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432036/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/200930/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.11.4767
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