Tungstate-Targeting of BKαβ(1) Channels Tunes ERK Phosphorylation and Cell Proliferation in Human Vascular Smooth Muscle

Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular voltage- and Ca(2+)-dependent large-conductance BKαβ(1) potassium channel, which m...

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Veröffentlicht in:PLoS One
Hauptverfasser: Fernández-Mariño, Ana Isabel, Cidad, Pilar, Zafra, Delia, Nocito, Laura, Domínguez, Jorge, Oliván-Viguera, Aida, Köhler, Ralf, López-López, José R., Pérez-García, María Teresa, Valverde, Miguel Ángel, Guinovart, Joan J., Fernández-Fernández, José M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320054/
https://ncbi.nlm.nih.gov/pubmed/25659150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118148
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