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Tuning Magnesium Sensitivity of BK Channels by Mutations
Intracellular Mg(2+) at physiological concentrations activates mSlo1 BK channels by binding to a metal-binding site in the cytosolic domain. Previous studies suggest that residues E374, Q397, and E399 are important in Mg(2+) binding. In the present study, we show that mutations of E374 or E399 to ot...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Biophysical Society
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1578465/ https://ncbi.nlm.nih.gov/pubmed/16877509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.090159 |
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