Association of Mitochondrial DNA levels with Frailty and All-Cause Mortality

Mitochondrial function is altered with age, and variants in mitochondrial DNA (mtDNA) modulate risk for several age-related disease states. However, the association of mtDNA copy number, a readily available marker which reflects mitochondrial depletion, energy reserves and oxidative stress, on aging...

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Veröffentlicht in:J Mol Med (Berl)
Hauptverfasser: Ashar, Foram N., Moes, Anna, Moore, Ann Z., Grove, Megan L., Chaves, Paulo H.M., Coresh, Josef, Newman, Anne B., Matteini, Amy M., Bandeen-Roche, Karen, Boerwinkle, Eric, Walston, Jeremy D., Arking, Dan E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319988/
https://ncbi.nlm.nih.gov/pubmed/25471480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-014-1233-3
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