Gradual Telomere Shortening and Increasing Chromosomal Instability among PanIN Grades and Normal Ductal Epithelia with and without Cancer in the Pancreas

A large body of evidence supports a key role for telomere dysfunction in carcinogenesis due to the induction of chromosomal instability. To study telomere shortening in precancerous pancreatic lesions, we measured telomere lengths using quantitative fluorescence in situ hybridization in the normal p...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Matsuda, Yoko, Ishiwata, Toshiyuki, Izumiyama-Shimomura, Naotaka, Hamayasu, Hideki, Fujiwara, Mutsunori, Tomita, Ken-ichiro, Hiraishi, Naoki, Nakamura, Ken-ichi, Ishikawa, Naoshi, Aida, Junko, Takubo, Kaiyo, Arai, Tomio
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319908/
https://ncbi.nlm.nih.gov/pubmed/25658358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117575
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