Gradual Telomere Shortening and Increasing Chromosomal Instability among PanIN Grades and Normal Ductal Epithelia with and without Cancer in the Pancreas

A large body of evidence supports a key role for telomere dysfunction in carcinogenesis due to the induction of chromosomal instability. To study telomere shortening in precancerous pancreatic lesions, we measured telomere lengths using quantitative fluorescence in situ hybridization in the normal p...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS One
Κύριοι συγγραφείς: Matsuda, Yoko, Ishiwata, Toshiyuki, Izumiyama-Shimomura, Naotaka, Hamayasu, Hideki, Fujiwara, Mutsunori, Tomita, Ken-ichiro, Hiraishi, Naoki, Nakamura, Ken-ichi, Ishikawa, Naoshi, Aida, Junko, Takubo, Kaiyo, Arai, Tomio
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2015
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319908/
https://ncbi.nlm.nih.gov/pubmed/25658358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117575
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