Gradual Telomere Shortening and Increasing Chromosomal Instability among PanIN Grades and Normal Ductal Epithelia with and without Cancer in the Pancreas

A large body of evidence supports a key role for telomere dysfunction in carcinogenesis due to the induction of chromosomal instability. To study telomere shortening in precancerous pancreatic lesions, we measured telomere lengths using quantitative fluorescence in situ hybridization in the normal p...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Matsuda, Yoko, Ishiwata, Toshiyuki, Izumiyama-Shimomura, Naotaka, Hamayasu, Hideki, Fujiwara, Mutsunori, Tomita, Ken-ichiro, Hiraishi, Naoki, Nakamura, Ken-ichi, Ishikawa, Naoshi, Aida, Junko, Takubo, Kaiyo, Arai, Tomio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319908/
https://ncbi.nlm.nih.gov/pubmed/25658358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117575
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