Preclinical Studies of the Potent and Selective Nicotinic α4β2 Receptor Ligand VMY-2-95

[Image: see text] The discovery and development of small molecules that antagonize neuronal nicotinic acetylcholine receptors may provide new ligands for evaluation in models of depression or addiction. We discovered a small molecule, VMY-2-95, a nAChR ligand with picomolar affinity and high selecti...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Kong, Hyesik, Song, Jun-ke, Yenugonda, Venkata Mahidhar, Zhang, Li, Shuo, Tian, Cheema, Amrita K., Kong, Yali, Du, Guan-hua, Brown, Milton L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319692/
https://ncbi.nlm.nih.gov/pubmed/25533629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp5003569
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