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VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells

The 2,6,9-trisubstituted purine group of cyclin dependent kinase inhibitors have the potential to be clinically relevant inhibitors of cancer cell proliferation. We have recently designed and synthesized a novel dansylated analog of purvalanol B, termed VMY-1-103, that inhibited cell cycle progressi...

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Detalhes bibliográficos
Main Authors: Ringer, Lymor, Sirajuddin, Paul, Yenugonda, Venkata Mahidhar, Ghosh, Anup, Divito, Kyle, Trabosh, Valerie, Patel, Yesha, Brophy, Amanda, Grindrod, Scott, Lisanti, Michael P, Rosenthal, Dean, Brown, Milton L, Avantaggiati, Maria Laura, Rodriguez, Olga, Albanese, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040852/
https://ncbi.nlm.nih.gov/pubmed/20574155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.4.12208
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