Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression

OBJECTIVE: To investigate the impact of the phophodiesterase-4 inhibition (PD-4-I) with rolipram on hepatic integrity in lipopolysaccharide (LPS) induced hyperinflammation. MATERIALS AND METHODS: Liver microcirculation in rats was obtained using intravital microscopy. Macrohemodynamic parameters, bl...

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Detalhes bibliográficos
Publicado no:J Pharmacol Pharmacother
Main Authors: Wollborn, Jakob, Wunder, Christian, Stix, Jana, Neuhaus, Winfried, Bruno, Rapahel R., Baar, Wolfgang, Flemming, Sven, Roewer, Norbert, Schlegel, Nicolas, Schick, Martin A.
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319242/
https://ncbi.nlm.nih.gov/pubmed/25709347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0976-500X.149138
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